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Rachel Kim
How NAD⁺ actually works in a cell — and where the mechanism story gets ahead of the human data.
Rachel writes about NAD⁺ biochemistry: the salvage pathway, how NR and NMN differ on the way in, what sirtuins and PARPs consume, and the recurring pattern in this category where a plausible mechanism is sold as a demonstrated result.
What they cover
- NAD⁺ biosynthesis and the salvage pathway
- Nicotinamide riboside versus nicotinamide mononucleotide
- Sirtuin and PARP enzymology
- Mitochondrial energy metabolism
- Coenzyme chemistry and cellular redox
- Mechanism-versus-evidence evaluation
Articles by Rachel Kim
17 pieces- What is NAD⁺? The coenzyme, the claims, and what the trials actually showEvidence
- NMN vs NR vs NAD⁺: what the difference actually is, and which has the better evidenceEvidence
- Is NAD⁺ a peptide? No — and what that tells you about who is selling itEvidence
- Liposomal NAD⁺: does the fat bubble actually get it in?Formats
- Nicotinamide riboside: the best-studied NAD⁺ precursor, and what its trials foundEvidence
- Liposomal NMN: a premium for solving a problem plain NMN does not haveFormats
- What does NAD⁺ do for the body? Two jobs, and one of them destroys itEvidence
- NAD⁺ vs NADH: the same molecule, two states — and two evidence basesEvidence
- NMN vs NAD⁺: why you cannot simply take the coenzyme itselfEvidence
- What does NAD mean in a medical note? Usually “no acute distress”Evidence
- Nicotinamide, niacinamide and niacin: what is actually differentEvidence
- NAD⁺ vs glutathione: how they are actually connected, and what clinics sellEvidence
- How much NAD⁺ should I take? The milligram is not one unitFormats
- NAD⁺ and fasting: the link, and how much of it was measuredEvidence
- NMN vs NMNH: the reduced form works better in a dish, never in a personEvidence
- Sermorelin vs NAD⁺: two molecules that share a checkout and nothing elseEvidence
- NAD⁺ patches: what is in them, and the one human study that used oneFormats