Skip to content
NAD+ Picks
← Research
Formats

NAD⁺ dosage: the doses used in trials, and why no honest chart exists

There is no NAD⁺ injection dosage chart, because there are no outcome trials to build one from. Here are the doses researchers actually administered, what products actually state, and the question to ask before you pay.

James Harper6 min read
Doses used in published human trialsNMN300 / 600 / 900 mg dailyNMN (safety)1,250 mg dailyNR (high-dose safety)1,500 mg twice dailyNR (retail serving)300 mg dailyWhat researchers administered — NOT a recommendation. Bars are relative, not to scale across compounds.

People searching for a NAD⁺ dosage chart are looking for something that does not exist, and the reason it does not exist is worth understanding before you go looking somewhere less careful.

A dosing chart for an approved drug comes from trials that established what dose produces what effect at what risk. Injectable NAD⁺ has no such trials. It is a compounded preparation, not FDA-approved, with no controlled outcome studies behind the benefits it is sold for — so there is nothing for a chart to be built from. Any site publishing one is inventing it.

What we can give you is the real thing underneath: the doses actual researchers administered, and the doses actual products state. Both are attributed. Neither is a recommendation, and the decision belongs to a clinician who knows your history.

Doses used in published human trials

NMN, dose-ranging. A randomized, double-blind, placebo-controlled trial randomized 80 healthy middle-aged adults (n = 80) for 60 days to placebo or 300 mg, 600 mg or 900 mg of NMN once daily. Blood NAD rose significantly in every NMN arm at day 30 and day 60 (all p ≤ 0.001) [1].

NMN, safety. A separate study administered 1,250 mg of β-NMN orally once daily for up to four weeks in 31 healthy adults aged 20–65, and reported no adverse events over the study period [2].

NR, high-dose safety. The NR-SAFE trial randomized 20 people with Parkinson’s disease 1:1 to NR 1,500 mg twice daily or placebo for four weeks. Its own background notes that doses above 2,000 mg daily had not previously been tested in humans[3] — which tells you how thin the high-dose evidence was before that study, and how far outside it most marketing sits.

NR, retail serving. Tru Niagen sells a 300 mg capsule it describes as its minimum daily recommended serving. That is a manufacturer’s serving size, not a trial dose.

What injectable providers state

Here is the finding that should shape how you shop: among the NAD⁺ injection providers we can verify, almost none publish the dose their monthly price buys. They publish $169 or $199 a month and leave the milligrams unstated.

That makes their prices genuinely incomparable, and it is the single most useful question to put to any of them before paying. If you get a number, our cost-per-milligram calculator turns competing offers into a figure you can line up. If you do not get a number, you have learned something about how they sell.

Why we will not publish a chart

We could rank for this query more easily by publishing a table of milligrams by body weight. We are not going to, and it is worth being explicit about why: that table would be fabricated. There is no outcome trial to derive it from, the product is not FDA-reviewed, and presenting invented numbers as clinical guidance for an injectable drug is the kind of thing that gets people hurt.

Take the trial doses above to a clinician and ask what is appropriate for you. If you want the cheaper, better-evidenced route first, that is an oral precursor — and see what is known about safety before starting anything.

Frequently asked

Is there a NAD⁺ injection dosage chart?
No honest one. A dosing chart is derived from trials establishing what dose produces what effect at what risk, and injectable NAD⁺ has no such trials — it is a compounded preparation with no controlled outcome studies. Any chart you find has been invented. What does exist is the doses researchers administered in published trials, which is a different thing and belongs in a conversation with a clinician.
What doses were used in NAD⁺ trials?
For NMN: 300, 600 and 900 mg once daily in a dose-ranging trial of 80 adults over 60 days, and 1,250 mg once daily for up to four weeks in a safety study of 31 adults. For NR: 1,500 mg twice daily for four weeks in a high-dose safety trial in Parkinson's disease, whose own background noted that doses above 2,000 mg daily had not previously been tested in humans. Retail NR is commonly sold at a 300 mg serving.
How much NAD⁺ is in the injection I am buying?
Most likely you have not been told. Among the injection providers we can verify, almost none publish the dose their monthly price buys — they publish $169 or $199 a month and leave the milligrams unstated. Ask directly before paying; without milligrams the prices are not comparable between providers.
How much NAD⁺ should I take?
That is a question for a licensed clinician who knows your history and your other medications, not for a website. We report what trials used and what products state, and we deliberately do not translate that into a recommendation for you.

Sources

  1. [1] Yi L, Maier AB, Tao R, et al. (2023). The efficacy and safety of β-nicotinamide mononucleotide (NMN) supplementation in healthy middle-aged adults: a randomized, multicenter, double-blind, placebo-controlled, parallel-group, dose-dependent clinical trial GeroScience. PMID 36482258
  2. [2] Fukamizu Y, Uchida Y, Shigekawa A, et al. (2022). Safety evaluation of β-nicotinamide mononucleotide oral administration in healthy adult men and women Scientific Reports. PMID 36002548
  3. [3] Berven H, Kverneng S, Sheard E, et al. (2023). NR-SAFE: a randomized, double-blind safety trial of high dose nicotinamide riboside in Parkinson's disease Nature Communications. PMID 38016950

Where to get it

Best NAD⁺ injections

Every injection provider we can verify, with the price each one publishes and an honest read of what injectable NAD⁺ has been shown to do.

Compare providers →

More in Formats